PUBLICATIONS

Selected work & complete record

Selected research landmarks and a complete peer-reviewed record spanning biological and solid-state nanopores, molecular recognition, disease biomarkers and emerging applications.

28Peer-reviewed articles

1,767+Google Scholar citations (October 2026)

19h-index

21i10-index

SELECTED PUBLICATIONS

Research landmarks

Six papers that capture the progression from nanopore transport and molecular recognition to biomarker analysis in complex samples.

Graphical abstract for the Small article on sulfated and unsulfated gut-hormone biomarkers in human serum

Small2026

Discrimination of Sulfated and Unsulfated Gut-Hormone Biomarkers in Human Serum

Identification of CCK-8 and SO₃-CCK-8 in a complex human-serum matrix using three complementary nanopore parameters.

Human serumPTMs

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Table of contents graphic for the ACS Nano article on oxytocin and its structural variants

ACS Nano2025

Discrimination of Oxytocin and Its Structural Variants by Nanopore

Structural-variant sensing of a behaviour-related neuropeptide through complementary single-molecule electrical signatures.

NeuropeptidesStructural variants

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Graphical abstract for the Chemical Science article on proline cis/trans amide isomers

Chemical Science2025

Single-Molecule Nanopore Sensing of Proline cis/trans Amide Isomers

Direct electrical resolution of conformational isomers generated by proline peptide-bond isomerisation.

ConformationIsomers

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Figure 1 from the Nature Communications perspective on nanopore sensing of protein and peptide conformation

Nature Communications2025

Nanopore Sensing of Protein and Peptide Conformation for Point-of-Care Applications

A perspective defining the translational potential of nanopore conformational sensing for future diagnostics.

PerspectiveDiagnostics

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ACS Central Science cover featuring the 2024 nanopore biomarker study

ACS Central Science2024

Identification and Detection of a Peptide Biomarker and Its Enantiomer by Nanopore

Single-molecule discrimination of chirality in a medically relevant peptide biomarker, featured on the journal cover.

ChiralityBiomarkersAerolysin

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Figure 5 from the Communications Materials article on single-sulfur atom discrimination of polysulfides

Communications Materials2020

Single-Sulfur Atom Discrimination of Polysulfides with a Protein Nanopore

Single-atom resolution applied to molecular species central to lithium–sulfur battery chemistry.

Single-atom sensingEnergy

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RESEARCH THEMES

A publication record organised around four questions

How can biological nanopores become molecular readers?

Aerolysin engineering, transport physics and electrical fingerprints.

How can solid-state nanopores analyse complex media?

Polymer-assisted transport, confinement and robust sensing conditions.

Can closely related disease biomarkers be resolved directly?

Peptide variants, conformers, stereoisomers and post-translational modifications.

Where else can single-molecule nanopore sensing contribute?

Digital polymers, battery chemistry and emerging molecular information systems.

COMPLETE RECORD

Peer-reviewed journal articles

Google Scholar ORCID

B. Cressiot is highlighted in each author list; underlining of B. Cressiot indicates his corresponding authorship; other authors’ corresponding-author markers are retained.

20264 publications (including accepted manuscripts)

Direct identification and quantification of peptide biomarkers in 20% human serum using a solid-state nanopore platform and machine learning

Y. Cai, Y. Liu, I. Khaled, B. Cressiot, L. Bacri and J. Pelta

Journal of the American Chemical Society (JACS) · 2026 · Accepted · DOI pending

Phase and Conformational Transitions in Biomolecules and Polymers with Nanopores

Y. Cai, Y. Liu, L. Bacri, B. Cressiot and J. Pelta^*

Small Methods · 2026 · Accepted manuscript · DOI pending

Identification and Discrimination of Sulfated and Unsulfated Gut-Hormone Biomarkers in Human Serum by Nanopore

L. Iesu, L. Bacri, J. Pelta^* and B. Cressiot

Small · 2026 · DOI: 10.1002/smll.74968

Scaling laws in confined media applied for biomarker detection

Y. Cai, B. Cressiot, M. Winterhalter, S. Balme, J. Pelta and L. Bacri

Nature Communications · 2026 · DOI: 10.1038/s41467-026-68912-4

20254 publications

DNA aggregation and resolubilization in the presence of polyamines probed at the single molecule level using nanopores

Y. Cai, B. Cressiot, S. Balme, E. Raspaud, L. Bacri and J. Pelta

Chemical Science · 2025 · DOI: 10.1039/D5SC05267J

Discrimination of oxytocin, a behavioral neuropeptide hormone, and its structural variants by nanopore

N. Meyer, L. Ratinho, S. Greive, L. Bacri, B. Morozzo della Rocca, M. Chinappi, J. Pelta^* and B. Cressiot

ACS Nano · 2025 · DOI: 10.1021/acsnano.5c08031

Single-molecule nanopore sensing of proline cis/trans amide isomers

L. Iesu, M. Sai, V. Torbeev, B. Kieffer, J. Pelta and B. Cressiot

Chemical Science · 2025 · DOI: 10.1039/D5SC01156F

Nanopore sensing of protein and peptide conformation for point-of-care applications

L. Ratinho, N. Meyer, S. Greive, B. Cressiot and J. Pelta^*

Nature Communications · 2025 · DOI: 10.1038/s41467-025-58509-8

20241 publication

Identification and Detection of a Peptide Biomarker and Its Enantiomer by Nanopore

L. Ratinho, L. Bacri, B. Thiebot, B. Cressiot and J. Pelta

ACS Central Science · 2024 · DOI: 10.1021/acscentsci.4c00020

20233 publications

Identification of Conformational Variants for Bradykinin Biomarker Peptides from a Biofluid Using a Nanopore and Machine Learning

S. Greive, L. Bacri, B. Cressiot and J. Pelta^*

ACS Nano · 2023 · DOI: 10.1021/acsnano.3c08433

Nanopore discrimination of coagulation biomarker derivatives and characterization of a post-translational modification

A. Stierlen, S. Greive, L. Bacri, P. Manivet, B. Cressiot and J. Pelta^*

ACS Central Science · 2023 · DOI: 10.1021/acscentsci.2c01256

Circulating Tumor Cells in Cancer Diagnostics and Prognostics by Single-Molecule and Single-Cell Characterization

T. Chowdhury, B. Cressiot, C. Parisi, G. Smolyakov, B. Thiebot, L. Trichet, F. M. Fernandes, J. Pelta and P. Manivet

ACS Sensors · 2023 · DOI: 10.1021/acssensors.2c02308

20223 publications

Dynamics of DNA Through Solid-State Nanopores Fabricated by Controlled Dielectric Breakdown

I. Tanimoto, J. Zhang, B. Cressiot, B. Le Pioufle, L. Bacri and J. Pelta

Chemistry – An Asian Journal · 2022 · DOI: 10.1002/asia.202200888

Focus on using nanopore technology for societal health, environmental, and energy challenges

I. Tanimoto, B. Cressiot, S. Greive, B. Le Pioufle, L. Bacri and J. Pelta

Nano Research · 2022 · DOI: 10.1007/s12274-022-4379-2

Fast Decoding of the First Steps of Protein Aggregation Using a Nanopipette

B. Cressiot and J. Pelta

ACS Central Science · 2022 · DOI: 10.1021/acscentsci.2c00267

20211 publication

Selective target protein detection using a decorated nanopore into a microfluidic device

I. Tanimoto, B. Cressiot, N. Jarroux, J. Roman, G. Patriarche, B. Le Pioufle, J. Pelta and L. Bacri

Biosensors and Bioelectronics · 2021 · DOI: 10.1016/j.bios.2021.113195

20202 publications

The promise of nanopore technology: Advances in the discrimination of protein sequences and chemical modifications

B. Cressiot, L. Bacri and J. Pelta

Small Methods · 2020 · DOI: 10.1002/smtd.202000090

Single-sulfur atom discrimination of polysulfides with a protein nanopore for improved batteries

F. Bétermier, B. Cressiot, G. Di Muccio, N. Jarroux, L. Bacri, B. Morozzo della Rocca, M. Chinappi, J. Pelta and J.-M. Tarascon

Communications Materials · 2020 · DOI: 10.1038/s43246-020-00056-4

20191 publication

Aerolysin, a powerful protein sensor for fundamental studies and development of upcoming applications

B. Cressiot, H. Ouldali, M. Pastoriza-Gallego, L. Bacri, G. van der Goot and J. Pelta

ACS Sensors · 2019 · DOI: 10.1021/acssensors.8b01636

20182 publications

Thermostable virus portal proteins as reprogrammable adapters for solid-state nanopore sensors

B. Cressiot, S. Greive, M. Mojtabavi, A. Antson and M. Wanunu

Nature Communications · 2018 · DOI: 10.1038/s41467-018-07116-x

Differential enzyme flexibility probed using solid-state nanopores

R. Hu, J. Rodrigues, P. Waduge, H. Yamazaki, B. Cressiot, Y. Chishti, L. Makowski, D. Yu, E. Shakhnovich, Q. Zhao and M. Wanunu

ACS Nano · 2018 · DOI: 10.1021/acsnano.8b00734

20172 publications

Porphyrin-assisted docking of a thermophage portal protein into lipid bilayers: nanopore engineering and characterization

B. Cressiot, S. Greive, W. Si, T. Pascoa, M. Mojtabavi, M. Chechik, H. Jenkins, X. Lu, K. Zhang, A. Aksimentiev, A. Antson and M. Wanunu

ACS Nano · 2017 · DOI: 10.1021/acsnano.7b06980

Nanopore-based measurements of protein size, fluctuations, and conformational changes

P. Waduge, R. Hu, P. Bandarkar, H. Yamazaki, B. Cressiot, Q. Zhao, P. Whitford and M. Wanunu

ACS Nano · 2017 · DOI: 10.1021/acsnano.7b01212

20151 publication

Dynamics and energy contributions for transport of unfolded pertactin through a protein nanopore

B. Cressiot, E. Braselmann, A. Oukhaled, A. Elcock, J. Pelta and P. L. Clark

ACS Nano · 2015 · DOI: 10.1021/acsnano.5b03053

20141 publication

Focus on protein unfolding through nanopores

B. Cressiot, A. Oukhaled, L. Bacri and J. Pelta

BioNanoScience · 2014 · DOI: 10.1007/s12668-014-0128-7

20122 publications

Protein transport through a narrow solid-state nanopore at high voltage: experiments and theory

B. Cressiot, A. Oukhaled, G. Patriarche, M. Pastoriza-Gallego, J.-M. Betton, L. Auvray, M. Muthukumar, L. Bacri and J. Pelta

ACS Nano · 2012 · DOI: 10.1021/nn301672g

Wild-type, mutant protein unfolding and phase transition detected by single-nanopore recording

C. Merstorf, B. Cressiot, M. Pastoriza-Gallego, A. Oukhaled, J.-M. Betton, L. Auvray and J. Pelta

ACS Chemical Biology · 2012 · DOI: 10.1021/cb2004737

20111 publication

Dynamics of completely unfolded and native proteins through solid-state nanopores as a function of electric driving force

A. Oukhaled, B. Cressiot, L. Bacri, M. Pastoriza-Gallego, J.-M. Betton, E. Bourhis, R. Jede, J. Gierak, L. Auvray and J. Pelta

ACS Nano · 2011 · DOI: 10.1021/nn1034795

BOOK CHAPTER ## Nanopore-based methodology

2012

DNA unzipping and protein unfolding using nanopores

C. Merstorf, B. Cressiot, M. Pastoriza-Gallego, A. Oukhaled, L. Bacri, J. Gierak, J. Pelta, L. Auvray and J. Mathé

Nanopore-Based Technology · Methods in Molecular Biology, vol. 870 · Humana Press · DOI: 10.1007/978-1-61779-773-6_4